Buck Institute
Professor
Julie Andersen, PhD
Professor at Buck Institute
CONTRIBUTIONS
BIO
Julie has a Ph.D. in neurobiological chemistry from UCLA and subsequently did her post-doctoral fellowship in the Department of Neurology at Harvard.
Presently, she is a professor and researcher at the Buck Institute, an independent biomedical research institute that is dedicated to investigating aging and age-related disease. Her lab is working on identifying novel therapeutics to delay or prevent the age-related molecular processes that drive neurodegenerative diseases. For example, she and other researchers at the Buck have been investigating compounds that could clear out senescent cells, which have been linked to age-related functional decline, as we have discussed previously on several shows.
Recently, Julie and her colleagues received a grant from the NIH to examine a natural bioactive known as urolithin A. Unfortunately, the capacity to generate urolithin A also appears to decline with age. To that end, Julie and her team plan to try to rejuvenate the gut microbiota of older mice using targeted probiotics, which should enhance production of urolithin A. They will then track neuropathology, memory loss, and mortality in a rodent model of Alzheimer’s disease, and compare outcomes in mice treated with urolithin A and controls.